There is live debate that will available this week for those that might be interested. The topic: Can early stopped trials result in misleading results of systematic reviews?
It’s sponsored by the Cochrane Collaboration and although the level of discussion is often not very technical, it does in my opinion provide a nice window into clinical research and as Tukey might put it “the real uncertainties involved”.
(As a disclaimer – I once assigned some reading from this group to my graduate students and they were embarrassed and annoyed at the awkward handling of even minor technical issues – but the statistical research community is not their target audience.)
I have a favourite in this debate, and a quick search on co-authors (not me) would likely tip that off to most members of this blog.
Here’s the directions kindly supplied by Jonathan Sterne, who will be in the chair.
Dear SMG Members,
By means of follow up to previous advertisements; the Discussion Meeting:”Can early stopped trials result in misleading results of systematic reviews?” will be broadcast live online (please see attached for further meeting details).
October 21 2010, 07.30 – 09.00 AM Denver Time (MDT)
(US East Coast +2 hours, UK +7, Central European Time plus 8)
To watch the meeting live, simply visit: www.cochrane.tv at your equivalent local time.
Should you have any queries or comments, before or after the meeting please do not hesitate to get in touch.
School of Social and Community Medicine
University of Bristol
Can early stopped trials result in misleading results
of systematic reviews?
Cochrane Colloquium, Keystone Colorado
October 21 2010, 07.30-09.00
Following the publication of empirical studies demonstrating differences between the results of trials that are stopped early and those that continue to their planned end of follow up, there has been intensive recent debate about whether the results of stopped early trials can mislead the clinician and consumer public. The Cochrane Bias Methods Group and Statistical Methods Group are delighted that two leading experts have agreed to present their views and lead a discussion on how review authors should address this issue.
Stopping early for benefit: is there a problem, and if so, what is it? Gordon Guyatt, McMaster University
Stopping at nothing? Some Dilemmas of Data Monitoring in Clinical Trials
Steven Goodman, Johns Hopkins University Schools of Medicine and Public Health