Michael Oakes pointed me to this excellent news article by Daniel Engber, subtitled, “There’s a replication crisis in biomedicine—and no one even knows how deep it runs.”
Engber suggests that the replication problem in biomedical research is worse than the much-publicized replication problem in psychology.
One reason, which I didn’t see Engber discussing, is financial incentives. Psychology researchers typically don’t like criticism of their published work: no surprise, they’re people like everyone else, also their careers are at stake. But in biomedicine, it’s not just careers and reputations on the line, it’s big money. Lots more incentives to cheat, or to use sloppy methods that can be twisted to get that magic p-value, etc.